Cohort Summary

BRCA · 1,000 patients

Patients

1,000

Median Age

59 yrs

OS Rate

89%

Therapy Records

1,000

Multimodal

with genomic/transcriptomic data

Molecular Subtypes

Age at Diagnosis

AJCC Stage Distribution

Overall Survival Status

Treatment Types

Kaplan-Meier Survival Curves

OS endpoint · 6 subtypes

Outcome

OSDFSPFS

Log-rank p = 0.101

Cox Hazard Analysis

Cox proportional-hazards · profile features only

Outcome

OSDFSPFS

C-index 0.773n 1,076events 150features: screen 28 → final 20

Selected features (6)

1Age_at_Diagnosis

2AJCC_PATHOLOGIC_TUMOR_STAGE

3ER_status

4Ethnicity

5Menopausal_status

6PATH_N_STAGE

Feature

0.10.250.51

Cohort Summary

BRCA · 1,000 patients

Patients

1,000

Median Age

59 yrs

OS Rate

89%

Therapy Records

1,000

Multimodal

with genomic/transcriptomic data

Molecular Subtypes

Age at Diagnosis

AJCC Stage Distribution

Overall Survival Status

Treatment Types

Kaplan-Meier Survival Curves

OS endpoint · 6 subtypes

Outcome

OSDFSPFS

Log-rank p = 0.101

Cox Hazard Analysis

Cox proportional-hazards · profile features only

Outcome

OSDFSPFS

C-index 0.773n 1,076events 150features: screen 28 → final 20

Selected features (6)

1Age_at_Diagnosis

2AJCC_PATHOLOGIC_TUMOR_STAGE

3ER_status

4Ethnicity

5Menopausal_status

6PATH_N_STAGE

Feature

0.10.250.51

Age_at_Diagnosis

1.02 (1.01–1.03)**

AJCC_PATHOLOGIC_TUMOR_STAGE_Stage II

0.97 (0.73–1.27)0.802

AJCC_PATHOLOGIC_TUMOR_STAGE_Stage III

1.40 (1.01–1.93)*

AJCC_PATHOLOGIC_TUMOR_STAGE_Stage IV

5.19 (2.81–9.57)***

ER_status_[Not Evaluated]

1.58 (0.85–2.93)0.147

ER_status_Negative

1.11 (0.79–1.58)0.547

ER_status_Positive

0.77 (0.55–1.08)0.125

Ethnicity_hispanic or latino

0.58 (0.27–1.27)0.173

Ethnicity_not hispanic or latino

1.30 (0.87–1.93)0.197

Ethnicity_not reported

0.87 (0.56–1.34)0.524

Menopausal_status_[Not Available]

2.58 (1.64–4.07)***

Menopausal_status_[Not Evaluated]

2.43 (0.36–16.36)0.363

Menopausal_status_[Unknown]

0.81 (0.25–2.59)0.722

Menopausal_status_Peri (6-12 months since last menstrual period)

0.71 (0.32–1.58)0.399

Menopausal_status_Post (prior bilateral ovariectomy OR >12 mo since LMP with no prior hysterectomy)

1.14 (0.85–1.52)0.395

Menopausal_status_Pre (<6 months since LMP AND no prior bilateral ovariectomy AND not on estrogen replacement)

0.84 (0.59–1.19)0.328

PATH_N_STAGE_N1

1.20 (0.91–1.57)0.197

PATH_N_STAGE_N2

1.35 (0.89–2.05)0.152

PATH_N_STAGE_N3

1.38 (0.84–2.28)0.207

PATH_N_STAGE_NX

3.67 (1.81–7.43)***

p<0.05 risk factor (HR>1) p<0.05 protective (HR<1) not significant*** p<0.001 · ** p<0.01 · * p<0.05